Angues et al. highlights links between COVID mRNA technology based Vaccines and Cancer, heightening risk of metastasis, failed remission etc., study worth reviewing! “SARS-CoV-2 Vaccination and the

Multi-Hit Hypothesis of Oncogenesis”; certain COVID-19 vaccines may generate a pro-tumorigenic milieu (i.e., a specific environment that could lead to neoplastic transformation) that predisposes some
‘Certain COVID-19 vaccines may generate a pro-tumorigenic milieu (i.e., a specific environment that could lead to neoplastic transformation) that predisposes some (stable) oncologic patients and survivors to cancer progression, recurrence, and/or metastasis.’

‘This hypothesis is based on biological plausibility and fulfillment of the multi-hit hypothesis of oncogenesis (i.e., induction of lymphopenia and inflammation, downregulation of angiotensin-converting enzyme 2 (ACE2) expression, activation of oncogenic cascades, sequestration of tumor suppressor proteins, dysregulation of the RNA-G quadruplex-protein binding system, alteration of type I interferon responses, unsilencing of retrotransposable elements, etc.) together with growing evidence and safety reports filed to Vaccine Adverse Effects Report System (VAERS) suggesting that some cancer patients experienced disease exacerbation or recurrence following COVID-19 vaccination.’

‘After reviewing the available literature, we are particularly concerned that certain COVID-19 vaccines may generate a pro-tumorigenic milieu (i.e., a specific environment that could lead to neoplastic transformation) that predisposes some (stable) oncologic patients and survivors to cancer progression, recurrence, and/or metastasis.
‘In light of the above and because some of these concerns (i.e., alteration of oncogenic pathways, promotion of inflammatory cascades, and dysregulation of the renin-angiotensin system) also apply to cancer patients infected with SARS-CoV-2, we encourage the scientific and medical community to urgently evaluate the impact of both COVID-19 and COVID-19 vaccination on cancer biology and tumor registries, adjusting public health recommendations accordingly.’

SARS-CoV-2 spike glycoprotein-based vaccines, particularly mRNA vaccines, have the potential to initiate a set of biological mechanisms that may collectively generate a (transient) pro-tumorigenic environment favorable to cancer progression and/or reactivation of DCCs. These adverse effects may be attributed to the pro-inflammatory action of the lipid nanoparticles (LNPs), the impaired type I interferon (IFN) response, the translational dysregulation of cellular microRNAs triggered by structurally modified mRNA (mRNA vaccines), and/or the unique nature, expression pattern, binding profile, and pro-inflammatory and tumorigenic effects of the produced antigens, namely, the SARS-CoV-2 spike protein and/or its subunits S1 and S2 (mRNA and adenovirus-vectorized vaccines) (Figure 1).’

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Author: Dr. Paul Alexander